Clinical Studies: 5 Mushrooms Reserve

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The research behind 5 Mushrooms Reserve

Guided by the science. Grown by nature.

5 Mushrooms Reserve combines five organic mushroom extracts for brain, gut and immune support.* Extraction is the step that pulls out the compounds researchers study, such as beta-glucans, so all five are extracts: four from the fruiting body, the part you would recognize as a mushroom, and one from chaga's sclerotia. Lion's mane and reishi make up the largest share, at 700 mg each.

Each study below is published and linked, with who took part, what they took, how much, for how long and what the researchers found.

Capsules, one serving (three capsules daily): Organic Lion's Mane Mushroom Extract 700 mg · Organic Reishi Mushroom Extract 700 mg · Organic Turkey Tail Mushroom Extract 300 mg · Organic Chaga Mushroom Extract 300 mg · Organic Cordyceps Mushroom Extract 100 mg.

Why it is built this way

Water first

Reishi has traditionally been prepared as decoctions and teas, and researchers point to two kinds of compounds in it: polysaccharides, such as beta-glucans, and triterpenes.[1] Our reishi is a 12:1 dual extract, made with water and then alcohol. The other four mushrooms are hot-water extracts.

Named by part

Researchers describe reishi in three parts: the fruiting body, the thread-like mycelium and the spores. The reishi trials pooled in a 2025 review varied in extraction method and in the type of supplement used.[1] So we name ours. Four are fruiting-body extracts, and the fifth is an extract of chaga's sclerotia. No mycelium, no grain.

What the studies found

Immune function

  • National Taiwan University, 2023: in a randomized, double-blind trial, 135 healthy adults aged 18 to 55 finished 84 days on one 200 mg capsule a day of a purified reishi beta-glucan or a placebo. At 12 weeks, T-cell counts (CD3, CD4 and CD8), natural killer cell counts and activity, and serum IgA were higher than in the placebo group.[2]
  • Disclosure: SBG Biomedical Research funded the trial, and the beta-glucan was made by Super Beta Glucan Inc.
  • Bundang Jesaeng General Hospital, Korea, 2015: in a four-week double-blind trial, 79 healthy men took 1.5 g a day of Cordyceps militaris prepared with ethanol, in capsules, or a placebo. Natural killer cell activity (p = 0.0010), lymphocyte proliferation (p ≤ 0.0001), IL-2 (p = 0.0096) and interferon-gamma (p = 0.0126) rose more than in the placebo group.[3] Cordyceps militaris is the species in our formula.

What we say about 5 Mushrooms Reserve: reishi supports healthy immune function.*

Gut health

  • Beth Israel Deaconess Medical Center and Harvard Medical School, 2014: researchers randomized 24 healthy volunteers into three groups and tracked their gut bacteria for eight weeks; 22 finished. The group taking a purified turkey tail compound, a protein-bound polysaccharide, showed clear, consistent changes in line with a prebiotic.[4] The study had NIH grant support.

What we say: turkey tail supports healthy immune function and gut health.*

Focus and memory

  • Japan, 2009: in a 16-week double-blind trial, 30 men and women aged 50 to 80, diagnosed with mild cognitive impairment, took 3 grams a day of tablets made from dried lion's mane powder, or a placebo. The lion's mane group scored significantly higher than the placebo group on a cognitive function scale at weeks 8, 12 and 16.[5]
  • Disclosure: the lead author worked at the mushroom laboratory of Hokuto Corporation in Japan.

What we say: lion's mane supports focus and memory.*

More from the blend

Cordyceps, 100 mg. Our cordyceps is Cordyceps militaris, the species in the Korean immune trial above, in the formula for energy and vitality support, the non-stimulant way.*

Chaga, 300 mg. Ours is a hot-water extract of chaga's sclerotia, the dark, dense growth chaga is known for, in the formula for antioxidant wellness support.* Chaga has a long history as a traditional tea in the birch forests of northern Europe and Siberia.

Every product's published third-party test results are on our testing page.

See 5 Mushrooms Reserve →

Sources

Last reviewed: September 23, 2026.

  1. Jafari A, et al. The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials. Food Science & Nutrition. 2025;13(6):e70423. PubMed 40510787. doi:10.1002/fsn3.70423.
  2. Chen SN, et al. Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial. Foods. 2023;12(3):659. PubMed 36766186. doi:10.3390/foods12030659.
  3. Kang HJ, et al. Cordyceps militaris Enhances Cell-Mediated Immunity in Healthy Korean Men. Journal of Medicinal Food. 2015;18(10):1164-1172. PubMed 26284906. doi:10.1089/jmf.2014.3350.
  4. Pallav K, et al. Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial. Gut Microbes. 2014;5(4):458-467. PubMed 25006989. doi:10.4161/gmic.29558.
  5. Mori K, et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research. 2009;23(3):367-372. PubMed 18844328. doi:10.1002/ptr.2634.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.