Clinical Studies: Liver Cleanse & Reset

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The research behind Liver Cleanse & Reset

Guided by the science. Grown by nature.

Liver Cleanse & Reset is a daily blend of seven organic botanicals that supports healthy liver enzyme levels (AST/ALT) and digestive comfort.* Artichoke, milk thistle and licorice, the three herbs in the trials below, go in as the same plant parts those trials studied: the leaf, the seed and the root.

Each study below is published and linked, with who took part, what they took, how much, for how long and what the researchers found.

Capsules, one serving (two capsules, once a day): Organic Artichoke Leaf 200 mg · Organic Beet Root 150 mg · Organic Dandelion Root 150 mg · Organic Milk Thistle Seed Extract 125 mg · Organic Burdock Root 100 mg · Organic Licorice Root 100 mg · Organic Turmeric Root 100 mg.

Why it is built this way

Milk thistle from the seed

The nine milk thistle trials pooled in 2024 tested silymarin, which comes from milk thistle seeds.[1] Our milk thistle is a seed extract, the one extract among the seven botanicals.

Artichoke from the leaf

Both artichoke studies on this page, a 2022 pooled analysis of seven trials and a six-week trial led by the University of Essen, used artichoke leaf.[2][3] Ours is the leaf too.

What the studies found

The largest pooled analysis first. In 2024, physicians at Mountain Vista Medical Center in Arizona and Airedale General Hospital in the UK pooled nine clinical trials covering 820 people with fatty liver disease: 412 took silymarin, from milk thistle seeds, and 408 were in control groups.[1] ALT averaged 17.12 IU/L lower and AST 12.56 IU/L lower than in the control groups (P < 0.004 and P < 0.0001).

Liver enzymes (ALT and AST)

  • Shahid Beheshti University of Medical Sciences, Tehran, 2022: nutrition researchers pooled seven randomized controlled trials covering 575 adults, including people with high cholesterol, type 2 diabetes, fatty liver disease or excess weight. The trials gave 50 to 2,700 mg a day of artichoke leaf extract or a placebo for 6 to 16 weeks. ALT was lower on artichoke than on placebo (standardized effect size, Hedges' g, −1.08; p = 0.002), and so was AST (−1.02; p = 0.007). The university funded the analysis.[2]
  • Qazvin University of Medical Sciences, Iran, 2012: 66 people with fatty liver disease and raised liver enzymes took 2 g a day of a water extract of licorice root or a placebo for two months in a double-blind trial. In the licorice group, ALT and AST fell significantly from the start of the study (p < 0.001 for each), while the placebo group's change was not significant.[4]
  • Shiraz University of Medical Sciences, Iran, 2022: 60 women with fatty liver disease took 1,000 mg a day of licorice root extract or a placebo for 12 weeks in a double-blind trial, with both groups advised to follow a weight-loss diet. ALT improved more than on placebo (p < 0.001).[5]

What we say about Liver Cleanse & Reset: it supports healthy liver enzyme levels (AST/ALT).*

Digestion (functional dyspepsia)

  • University of Essen, Germany, 2003: 247 people with functional dyspepsia, which is long-running indigestion with no structural cause, enrolled in a six-week, double-blind, multicenter trial, and 244 were analyzed. They took 1,920 mg a day of a commercial artichoke leaf extract or a placebo. Overall symptom improvement was greater on the extract than on placebo (8.3 vs 6.7 on the trial's scale, P < 0.01), and so was the improvement in quality of life (P < 0.01).[3]
  • Two centers in Bangalore, India, 2012: 50 people with functional dyspepsia, 25 per group, took 150 mg a day of a flavonoid-rich licorice root extract low in glycyrrhizin, or a placebo, for 30 days in a double-blind trial. Symptom scores and quality of life improved more than on placebo at day 15 and day 30 (P ≤ 0.05).[6]
  • Disclosure: seven of the eleven authors of the Bangalore trial worked at Natural Remedies, the company that makes the extract.
  • Artichoke leaf's use for bile flow is a long herbal tradition. The modern trials measured digestion and liver enzymes.

What we say: it supports digestive comfort.*

The rest of the blend

Dandelion root. Dandelion root has been a mainstay of traditional liver tonics for generations.

Burdock root. Burdock root is dandelion's old farm-tonic companion, and the two have long been used together.

Turmeric root. Turmeric goes in as the whole organic root, the golden spice long used in kitchens and herbal traditions.

Beet root. Beet root rounds out the seven.

Every product's published third-party test results are on our testing page.

See Liver Cleanse & Reset →

Sources

Last reviewed: September 23, 2026.

  1. Malik A, Malik M, Qureshi S. Effects of silymarin use on liver enzymes and metabolic factors in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis. Canadian Liver Journal. 2024;7(1):40-53. PubMed 38505782. doi:10.3138/canlivj-2023-0021.
  2. Amini MR, et al. Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Clinical Nutrition Research. 2022;11(3):228-239. PubMed 35949559. doi:10.7762/cnr.2022.11.3.228.
  3. Holtmann G, et al. Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial. Alimentary Pharmacology & Therapeutics. 2003;18(11-12):1099-1105. PubMed 14653829. doi:10.1046/j.1365-2036.2003.01767.x.
  4. Hajiaghamohammadi AA, Ziaee A, Samimi R. The efficacy of licorice root extract in decreasing transaminase activities in non-alcoholic fatty liver disease: a randomized controlled clinical trial. Phytotherapy Research. 2012;26(9):1381-1384. PubMed 22308054. doi:10.1002/ptr.3728.
  5. Rostamizadeh P, et al. Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double-blind clinical trial. Phytotherapy Research. 2022;36(10):3949-3956. PubMed 35785498. doi:10.1002/ptr.7543.
  6. Raveendra KR, et al. An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine. 2012;2012:216970. PubMed 21747893. doi:10.1155/2012/216970.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.